What happens in the brain on Psilocybin Continue to article

Related Articles

Mushly. Edible, Medical, Psilocybin & Mushroom Info
How Psilocybin Works

By Mushly.

Published on 23 November 2022

Psilocybin, the compound found in magic mushrooms, improves connections between different regions of the brain in depressed people. This allows for more communication and activity between different parts of the brain. Psilocybin also decreases network activity in the "default mode network," which is associated with self-reflection and rumination. These effects likely contribute to the antidepressant effects of psilocybin.


The Effects of Psilocybin

Psilocybin, the active ingredient in hallucinogenic mushrooms, affects the brain in many ways. It increases activity in the visual cortex, leading to changes in perception. It also decreases network activity in the "default mode network." This lowered activity is associated with ego dissolution, a complete loss of subjective self-identity. Psilocybin also reduces neural activity in the claustrum by 15% to 30%.


Short-Term Effects

Psychedelic drugs like psilocybin affect the brain by increasing activity in the visual cortex and other areas responsible for abstract thinking and thought analysis. These changes can lead to short-term effects like nausea, increased perspiration, numbing, and tremors. Psychedelic drugs can also cause long-term changes in the brain, including an increase in the number of connections between different areas of the brain.


Long-Term Effects

Shrooms affect the brain in a variety of ways, both in the short and long term. In the short term, they can cause changes in perception, increased blood pressure and heart rate, and body tremors. In the long term, they can lead to reduced negative mood, increased positive mood, and reduced amygdala response to negative affective stimuli.


Risks and Side Effects

Psychedelic mushrooms contain compounds that act on the brain to cause their effects. Taking these shrooms can cause hallucinatory sensory experiences, dilated pupils, and changes in breathing. Magic mushrooms can also cause coordination loss and sensory distortions. Some of the risks associated with using psychedelic mushrooms include psychological distress, bad trips, and amygdala response to negative affective stimuli. 


What to Expect After Taking Psilocybin

Taking these shrooms can cause hallucinatory sensory experiences, changes in thinking and perception, and feelings of paranoia or anxiety. Psilocybin affects the brain's prefrontal cortex, which regulates abstract thinking, thought analysis, and decision-making. This can lead to lowered activity in the claustrum, a part of the brain associated with ego dissolution. Cross-tolerance is another long-lasting effect of magic mushroom abuse, which means that the user will need increasingly larger doses to achieve the same effect. However, with normal use, any tolerance subsides after about 2 weeks to a month, individual dependant.

The Afterglow

The Afterglow: In The Brain, Studies have shown that serotonergic psychedelics like LSD (lysergic acid diethylamide), psilocybin mushrooms, and DMT can have long-lasting effects on the brain. Acute psilocybin effects include reduced negative mood, increased positive mood, and reduced amygdala response to negative affective stimuli. Scientists reviewing fMRI brain scans of people who've ingested psilocybin and people who've taken a placebo discovered that magic mushrooms change brain activity in regions associated with emotion and cognition. Conclusions: These findings in a small cohort indicate that psilocybin affects Electrical Communications Network(ECN) function within the psychedelic experience and may have long-lasting effects on emotion and cognition.


Integrated change and moving forward

Psychedelic drugs, such as LSD and psilocybin, work by diffusing through the brain and activating serotonin receptors. This disrupts neural activity and can lead to changes in mood, perception, and cognition. While the exact mechanisms are not fully understood, it is thought that psychedelics may be able to alleviate some psychiatric symptoms by resetting brain circuits. A recent study found that psilocybin can acutely reduce symptoms of depression and anxiety in some people. These effects were long-lasting, with participants reporting improvements in their mood even after one year. This subsequently provides the base for any growth moving forward, as one is able to break free from their old and stuck patterns, create and immerse in new ones, and from sustaining that change continues to reap and sow that same change back in.


Becoming our best self

Psychedelic drugs have been shown to help people become more open-minded and less judgmental. Psilocybin, in particular, has been shown to help improve emotional distress and cognitive functioning. These changes can be used as a means to become our best selves. As we are now able to be more neutral to not just negative affective stimuli, but also positive ones. While this may sound counter-intuitive, it means that we are able to be present in our lives, without chasing a sensation of good or bad, this is when we really start participating. If we are forever swayed toward what we are running toward or away from, then we are forever running from where we really are. Only when we become cognizant of this space we are in, holistically, are we able to effect any change in our life.  From this space, we naturally see how we choose to live and effect any desired changes.



Disclaimer: This article is written purely for educational reasons. Mushly in no way suggests the use, sale, or ownership of any illicit substances. Furthermore, take the time to be aware of the legislature and what that means for you, as decided by the governing body of the country and city you live in.